Sony Ericsson hosted the revolutionary event to celebrate the start of this year's Sony Ericsson Open March 26 to April 6.
Also see: 'Sania needs to put in extra effort'
According to the draw released on Monday, both Nadal, seeded second in the men's, and Serena, seeded eighth have received first round byes.
Serena, who has been drawn in the same half as Venus Williams and world number one Justine Henin, is the defending champion at Miami.