Vicky (Akshay Kumar) is a budding pop singer madly in love with Anjali (Amisha Patel). He is completely besotted with her. But fate has other plans, and an accident sees Amisha bedridden.

Meanwhile, Vicky has already signed a contract with an international music company, and must move to Canada. Anjali persuades Vicky to put career before love, and he reluctantly leaves for Canada.

There, he meets Natasha (Karisma), chief of the music company he has signed up with. Vicky sings his way to superstardom. And he still loves and draws inspiration from Anjali.

Natasha, meanwhile, has fallen in love with Vicky. In fact, she and Vicky were college buddies, and she had a crush on him since then. Vicky and Natasha get physically intimate.

But Vicky is repentant. He carries the guilt of having betrayed Anjali. Will he go back to her, or begin a new chapter in his life?

Mere Jeevan Saathi is the second Akshay Kumar film to hit theatres this year. And it comes after the disastrous Family.